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US 11,891,392 B2Granted
Pharmacophore for trail induction
AssigneeThe Scripps Research Institute
InventorsKim D. Janda, Nicholas T. Jacob, Jonathan W. Lockner
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Abstract
There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein.
Claims5
A method for making a compound 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9,-hexahydroimidazo[1,2-α]pyrido[3,4-e]pyrimidin-5(4H)-one
- comprising the step of mixing N-(2-methylbenzyl)-4,5-dihydro-1H-imidazol-2-amine with methyl 1-benzyl-4-oxopiperidine-3-carboxylate to afford the compound.
Dependencies are inferred from the claim text.