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US 11,891,386 B2Granted
Indole compounds and their use
AssigneeAriagen, Inc.
InventorsPeter Colabuono, Graham Johnson, David Douglas Manning, Mark Allan Wolf
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.
Claims19
A method of stimulating the immune system in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of Structural Formula 8, or an enantiomer, diastereomer, or pharmaceutically acceptable salt thereof:
- wherein R2 is a C1-C6 alkyl substituted with one or more hydroxyl, alkoxy, nitro, or cyano, and the compound is enantiomerically pure;
- or
- wherein R2 is heteroaryl or
- and R2a is H, C1-C6 alkyl, hydroxy, thioalkoxy (—S-alkyl), cyano (—CN), or amino;
- and
- R4, R5, R6, and R7, are each, independently, hydrogen or halo.
3 more elements
Dependencies are inferred from the claim text.