Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AssigneeAerie Pharmaceuticals, Inc.
InventorsMitchell A. deLong, Jill M. Sturdivant, Cynthia L. Lichorowic, Andriy Kornilov
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Abstract
Provided herein are amino isoquinolinyl amide and sulfonamide compounds that affect the function of kinases and other proteins in a cell and that are useful as therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and retinal diseases, as anti-inflammatory agents, for the treatment of cardiovascular diseases, and for diseases characterized by abnormal growth, such as cancers.
Claims27
A method of treating an ocular disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is H, halo, —CN, —C1-6 alkyl, —C1-6 alkoxyl, —C1-6 haloalkyl, —C1-6 haloalkoxyl;
- R2 is H or halo;
- X is —(C1-5 heteroaryl)-R3;
- and
- R3 is —C2-6 heterocyclyl, or —C1-6 heteroalkyl.
A method of reducing intraocular pressure in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is H, halo, —CN, —C1-6 alkyl, —C1-6 alkoxyl, —C1-6 haloalkyl, —C1-6 haloalkoxyl;
- R2 is H or halo;
- X is —(C1-5 heteroaryl)-R3;
- and
- R3 is —C2-6 heterocyclyl, or —C1-6 heteroalkyl.
A method of modulating kinase activity in a cell, comprising contacting the cell with an effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is H, halo, —CN, —C1-6 alkyl, —C1-6 alkoxyl, —C1-6 haloalkyl, —C1-6 haloalkoxyl;
- R2 is H or halo;
- X is —(C1-5 heteroaryl)-R3;
- and
- R3 is —C2-6 heterocyclyl, or —C1-6 heteroalkyl.
Dependencies are inferred from the claim text.