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US 11,891,375 B2Granted
Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
AssigneeMoehs Iberica, S.L.
InventorsAbdeslam Akhatou, Alicia Dobarro Rodríguez
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Abstract
A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.
Claims19
A method for preparing a compound of formula (I) or a stereoisomer or salt thereof
- which comprises reacting a compound of formula (II) with N,N-dimethylformamide diethyl acetal
A crystalline form of a compound of formula (III)
- characterized in that the X-ray powder diffraction spectrum thereof measured with CuKα radiation comprises peaks at 12.8, 15.5, 16.6, 17.9, 21.8, 22.1, 23.6, 25.0, 25.7, 27.1, 30.1 °2θ±0.2 °2θ.
Dependencies are inferred from the claim text.