Compounds for binding proprotein convertase subtilisin/kexin type 9

A method of treating a disease or condition, wherein the disease or condition is selected from hypocholesterolemia, coronary disease, hypertension, hypercholesterolemia, atherosclerosis, and diabetes, the method comprising administering to a patient in need thereof a compound of Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• m is 0, 1, or 2;
• X1 is N;
• X2, X3, and X4 are each independently CR2 or CR2R2;
• ring B is a six-membered ring comprising one or more double bonds;
• X5 and X6 are CR2;
• X7 is C;
• ring A is:
• where the wavy line in ring A indicates the point of attachment to
• L is a bond;
• R1 in each instance is independently halo or C1-6 alkyl optionally substituted with halo or hydroxy;
• R2 in each instance is independently hydrogen, halo, or C1-6 alkyl optionally substituted with halo or hydroxy
• R3 is halo, C1-6 alkyl, C3-6 cycloalkyl, or aryl;
• wherein each C1-6 alkyl, C3-6 cycloalkyl, or aryl of R3 is optionally substituted with 1 to 3 substituents independently selected from halo and hydroxy;
• and
• R4 is hydrogen or C1-6 alkyl;
• provided that when A is attached via a carbon atom to the remainder of the molecule and m is other than 0, then R1 is not appended to the same carbon atom.