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US 11,891,367 B2Granted
Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide
AssigneeProvepharm Life Solutions
InventorsMichel Feraud, Babak Sayah, Stéphane Queru, Marina Laurent
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Abstract
Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.
Claims19
A one-pot process for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the process using phenothiazine as a starting product and comprising the following steps:
- a) treating phenothiazine with diiodine, and
- b) treating the reaction medium directly resulting from step a) with dimethylamine,
- wherein, in step b), the dimethylamine is introduced into the reaction medium in the form of a solution in water, or a mixture of water with one or more of methanol, ethanol, or tetrahydrofuran.
Dependencies are inferred from the claim text.