Surface treatment system and method for subcutaneous device

A method of modifying a medical device, the method comprising:

• treating a portion of the medical device with cold plasma;
• functionalizing the plasma-treated portion with a polymer;
• and
• immobilizing a biomolecule through a linking molecule located on a surface of the plasma-treated treated portion,
• wherein:
• immobilizing the biomolecule through the linking molecule includes generating and maintaining a non-thermal atmospheric pressure plasma at a temperature at or below about 60° C.,
• the linking molecule is deposited onto the plasma-treated portion by exposing the plasma-treated portion to a first plasma jet and the linking molecule to generate a linking layer on the plasma-treated portion,
• the method further comprises depositing the biomolecule onto the linking layer by exposing the linking layer to a second plasma jet and the biomolecule,
• the biomolecule comprises a hyaluronic acid species, and
• the biomolecule comprises a formulation compound comprising the formula:

A method of manufacturing a medical device, the method comprising:

• providing a subcutaneous part configured to be positioned subcutaneously in a user;
• performing a surface treatment on a portion of the subcutaneous part, and
• forming one or more apertures through the subcutaneous part prior to performing the surface treatment on the portion of the subcutaneous part,
• wherein performing the surface treatment on the portion of the subcutaneous part includes
• exposing a treated portion of the subcutaneous part to cold atmospheric plasma to create a linking layer thereon and
• functionalizing the linking layer with a biomolecule configured to reduce a foreign body response to the subcutaneous part when the subcutaneous part is subcutaneously positioned in the user,
• and wherein performing the surface treatment on the portion of the subcutaneous part does not close the one or more apertures.