Methods for potentiating antimicrobial agents
AssigneeBeyond Air, Inc.
InventorsYossef Av-Gay, David Greenberg, Asher Tal
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Abstract
The invention provides a method of treating a subject having a medical condition associated with a pathogenic microorganism, the method comprising administering to said subject a potentiating effective amount of nitric oxide; and administering to said subject a therapeutically effective amount of an antimicrobial agent, wherein said antimicrobial agent is other than said nitric oxide.
Claims18
A method of treating a subject having a medical condition associated with a pathogenic microorganism, the method comprising:
- (i) administering to said subject a potentiating effective amount of nitric oxide by inhalation;
- and
- (ii) administering to said subject a therapeutically effective amount of an antimicrobial agent,
- wherein said antimicrobial agent is other than said nitric oxide, and
- wherein said antimicrobial agent is inactive when used alone against said pathogenic microorganism.
A method of treating a subject having a medical condition associated with a pathogenic microorganism in which an antimicrobial resistance has been uncovered following treating said subject with said antimicrobial agent, the method comprising:
- (i) administering to said subject, following a treatment with said antimicrobial agent and uncovering said antimicrobial resistance, a re-sensitizing effective amount of nitric oxide;
- (ii) administering to said subject a therapeutically effective amount of said antimicrobial agent,
- wherein said antimicrobial agent is other than said nitric oxide and said re-sensitizing effective amount of nitric oxide is lower than a therapeutically effective amount of nitric oxide with respect to said microorganism.
A method for sensitizing or re-sensitizing a microorganism to an antimicrobial agent, comprising:
- (i) contacting said microorganism with a sensitizing or re-sensitizing effective amount of nitric oxide;
- and
- (ii) contacting said microorganism with a therapeutically effective amount of said antimicrobial agent, wherein said antimicrobial agent is other than said nitric oxide and said sensitizing or re-sensitizing effective amount being lower than a therapeutically effective amount of said nitric oxide with respect to said pathogenic microorganism;
- and
- wherein said pathogenic microorganism exhibits a resistance to said antimicrobial agent prior to said administering said potentiating effective amount of nitric oxide.
Dependencies are inferred from the claim text.