Surface textures of medical devices
AssigneeInstructure Labs B.V.
InventorNoel Lee Davison
Life of this patent
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Abstract
One or more embodiments of the present invention are directed to a medical device having a textured surface with an arithmetical mean height value (Sa) below 3.0 μm and a developed interfacial area ratio (Sdr) above 1.0 and a density of peaks (Spd) above 1×106 peaks/mm2; a process of preparing such a medical device using a microstructured template; and a method of treating a mammal with such a medical device.
Claims20
A medical implant adapted for placement inside of or on a body surface of a subject, the medical implant comprising:
- a textured surface which, in use, directly contacts one or more of biological fluid, tissue, and cells of the subject, the textured surface having an arithmetical mean height value (Sa) below 3.0 μm, a developed interfacial area ratio (Sdr) above 1.0, and a density of peaks (Spd) above 1×106 peaks/mm2, wherein the Sa, the Sdr, and the Spd are measured according to ISO 25178 using a Gaussian low pass S-filter with a nesting index value of at least 0.25 μm, and
- whereby the contact effects one or more of:
- limiting fibrosis, limiting foreign body response, resisting bacterial and viral adhesion and proliferation, resisting blood coagulation and thrombosis, promoting biological adhesion and integration of biological tissue, guiding cell differentiation, instructing cell migration, promoting cell survival, and perpetuating a selected cellular phenotype limiting fibrosis, with respect to the medical implant.
A medical device adapted for placement inside of or on a body surface of a subject, the medical device comprising:
- a textured surface having an arithmetical mean height value (Sa) of from 0.3 to 5.0 μm, a developed interfacial area ratio (Sdr) above 1.0, a density of peaks (Spd) above 1×106 peaks/mm2, and a surface root mean square gradient (Sdq) of from 1.0 to 8.0, wherein the Sa, Sdr, Spd, and Sdq are measured according to ISO 25178 using a Gaussian low pass S-filter with a nesting index value of at least 0.25 μm, and
- wherein, in use, the textured surface directly contacts one or more of biological fluid, tissue, and cells of the subject.
Dependencies are inferred from the claim text.