Lipid formulations for delivery of messenger RNA
AssigneesTranslate Bio, Inc., Massachusetts Institute of Technology
InventorsMichael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
Life of this patent
Estimating the term…
Abstract
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
Claims20
A method of delivery of messenger RNA (mRNA) in vivo, comprising administering to a subject in need of delivery a composition comprising an mRNA that encodes Factor IX (FIX), wherein said mRNA is encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo;
- and
- wherein the liposome comprises a cationic lipid of formula I-g:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- RL is C1-50 alkyl, C2-50 alkenyl, or C2-50 alkynyl, and
- wherein the mRNA has a length of or greater than about 0.5 kb.
Dependencies are inferred from the claim text.