Biocompatible protein-based particles and methods thereof
AssigneePetvivo Holdings, Inc.
InventorDavid B. Masters
Life of this patent
Estimating the term…
Abstract
The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein-based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder . . . ) and organ(s) (e.g. bladder, lips, vagina, penis, urethra . . . ). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.
Claims19
A method of treating or enhancing the function of a joint comprising:
- administering a plurality of particles to the synovial space or the area proximal to the periosteum in the joint of a patient, said particles comprising one or more biocoacervate material(s) precipitated from a solution comprising effective proportions of two or more soluble biocompatible proteins, one or more glycosaminoglycans and one or more biocompatible solvents,
- wherein the biocoacervate material(s) are shape-holding solid precipitate,
- wherein all or a portion of the particles are crosslinked with one or more crosslinking agents,
- wherein the two or more soluble biocompatible proteins comprise Type I collagen and elastin,
- wherein the one or more glycosaminoglycans comprise heparin,
- wherein the biocoacervate material(s) comprise a ratio of about 2 parts of elastin to about 1 part of the one or more glycosaminoglycans to at least one of:
- about 7 parts of Type I collagen, and about 7.5 parts of Type I collagen, and
- wherein the particles have a size of approximately 500 nm to 1000 μm.
Dependencies are inferred from the claim text.