Ultrasound-induced drug delivery system using drug carrier comprising nanobubbles and drug
AssigneesSahmyook University Industry-Academic Cooperation Foundation, N To B Co., Ltd.
InventorMyoung Hwan Park
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Abstract
An ultrasound-induced drug delivery system is described, using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule, and a method for preparing the drug delivery system, by generating the nanobubbles in an oil into which the drug is dissolved using a nanobubble generator, and then microencapsulating them. The drug delivery system has an effect of maximizing a drug delivery efficiency as the nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system. Since the drug delivery system contains a plurality of nanobubbles within the microcapsules, it can also be used as a contrast agent, or can be used to simultaneously perform in vivo diagnosis and treatment.
Claims6
A method for preparing a drug delivery system in the form of microcapsules in which both a drug and nanobubbles are microencapsulated, the method comprising the steps of:
- (a) dissolving the drug in an organic solvent, and then mixing it with an oil to prepare a mixed solution;
- (b) removing the organic solvent from the mixed solution;
- (c) preparing an oil solution containing both the drug and the nanobubbles, by generating the nanobubbles in the mixed solution from which the organic solvent has been removed;
- and
- (d) mixing the oil solution in an aqueous solution containing a surfactant,
- wherein the drug delivery system in the form of the microcapsules is prepared by encapsulating the drug together with the nanobubbles, both being contained in the oil,
- wherein the drug is a fat-soluble drug, and
- wherein the organic solvent is completely removed from the mixed solution using a vacuum or rotary concentrator.
Dependencies are inferred from the claim text.