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US 11,890,367 B1Granted
Anti-aging composition based on mixed ester of stilbenic extract
AssigneeKing Faisal University
InventorImene Bayach
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Abstract
A cosmetic composition having an anti-aging effect, and particularly cosmetic compositions comprising natural polyphenols, such as oligostilbenes. The polyphenols are stabilized by forming mixed polyphenol-vitamin E esters. These esters may be hydrolyzed by esterases of the skin, when topically applied, to regenerate the active ingredients in their native state and thereby treat and/or reduce skin aging or other skin diseases or deteriorations.
Claims20
A mixed diester of oligostilbene with vitamin E having the formula:
- wherein n is 1 or 2.
A process for coupling a polyphenol to vitamin E, the process comprising:
- esterifying vitamin E with a diacid anhydride to obtain a vitamin E diacid ester;
- chlorinating the vitamin E diacid ester with a chloride reagent to obtain a vitamin E diacid chloride;
- dissolving an extract of the polyphenol and 4-Dimethylaminopyridine (DMAP) in pyridine to obtain a polyphenol solution;
- and
- adding the vitamin E diacid chloride to the polyphenol solution to obtain a coupled polyphenol-vitamin E product.
2 more elements
Dependencies are inferred from the claim text.