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US 11,890,364 B2Granted
Composition for prevention or treatment of hair loss
AssigneeGood T Cells, Inc.
InventorsBeom Seok Kim, Jung Ho Kim
Life of this patent
Estimating the term…
Abstract
The present invention relates to a composition for prevention or treatment of hair loss. The composition is effectively delivered into hair papilla cells in a hair loss area, which is a target area, wherein a cytokine or enzyme highly expressed in the hair loss area causes a drug to be separated from a compound contained in the composition so that the drug effectively exhibits activity, which ultimately promotes hair growth and/or hair regrowth.
Claims11
A method for preventing or treating hair loss, comprising administering, to a target individual, an effective amount of a compound represented by Formula 1:
- P-W-L1-M-A [Formula 1]
- in which
- P is a protein transduction domain (PTD);
- W is a direct bond or includes at least one amino acid;
- L1 is a linker, wherein L1 is represented by Formula 3 or Formula 4,
- in which Formulas 3 and 4, * is a site where a bond is formed;
- M is a linker represented by Formula 2;
- *-X-L2-* [Formula 2]
- in which
- * is a site where a bond is formed,
- X is a cleavage site that is recognized by a caspase and which is cleavable thereby in hair papilla cells at a hair loss area, and
- L2 is a linker, wherein L2 is represented by Formula 5,
- in which * is a site where a bond is formed;
- and
- A is a drug for prevention or treatment of hair loss, wherein A is selected from the group consisting of finasteride, dutasteride and minoxidil.
12 more elements
Dependencies are inferred from the claim text.