Plectin-targeted liposomes/PARP inhibitor in the treatment of cancer
AssigneeUniversity of Virginia Patent Foundation
InventorsKimberly A. Kelly, Siva Sai Krishna Dasa
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Abstract
The present invention provides compositions and methods to treat cancer.
Claims11
A method to treat cancer comprising administrating to a subject in need thereof an effective amount of a composition comprising a Plectin Targeted Peptide (PTP) conjugated nanoparticle, wherein the PTP is on the surface of the nanoparticle and the nanoparticle encapsulates a payload, wherein the payload is passively loaded, wherein cells of the cancer have mutated BRCA1/2 and express plectin.
A method to decrease tumor volume comprising administering to a subject in need thereof an effective amount of a composition comprising a Plectin Targeted Peptide (PTP) conjugated nanoparticle, wherein the PTP is on the surface of the nanoparticle and the nanoparticle encapsulates a payload, wherein the payload is passively loaded, wherein cells of the tumor have mutated BRCA1/2 and express plectin.
Dependencies are inferred from the claim text.