Back to results
US 11,890,347 B2Granted
PH-responsive polymer and drug delivery system
AssigneeTokyo Institute of Technology
InventorsNobuhiro Nishiyama, Hiroyasu Takemoto, Abdul-Hackam Ranneh, Keishiro Tomoda, Takahiro Nomoto, Makoto Matsui
Life of this patent
Estimating the term…
Abstract
A pH-responsive polymer formed of a biocompatible polymer to which a group which is electrically neutral under pH environments of more than 7 and which changes to be cationic at pH 7 or less is bonded.
Claims9
A pH-responsive polymer, comprising:
- a biocompatible polymer in which a side chain thereof including a group represented by Formula (1), a group represented by Formula (2), or a group represented by Formula (3) is bonded via a linking group containing an amide bond,
- wherein the biocompatible polymer is polyglutamic acid or polyaspartic acid,
- wherein the linking group containing an amide bond is bonded to the main chain of the biocompatible polymer, and the side chain is electrically neutral under pH environments of 7.2 to 7.6 and which changes to be cationic under pH environments of 6.0 to 6.6:
- in Formulas (1) to (3), n represents an integer of 1 to 3, and * represents a bond.
1 more element
Dependencies are inferred from the claim text.