Inactivated whole-virus influenza vaccine and method for preparing same
AssigneesDenka Company Limited, National University Corporation Kumamoto University
InventorsRyotaro Mitsumata, Shogo Misumi, Naoki Kishimoto, Takuma Gotanda, Nagisa Nakata
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Abstract
An inactivated whole-virus influenza vaccine may have its antibody-inducing ability is maintained or enhanced and may cause fewer side reactions. A method for preparing an inactivated whole-virus influenza vaccine may use an embryonated chicken egg method, including subjecting a virus solution including a whole influenza virus collected from embryonated chicken eggs to a hypotonic treatment.
Claims4
A method for preparing an inactivated whole-virus influenza vaccine using an embryonated chicken egg technique, the method comprising:
- subjecting a virus solution, comprising whole influenza virus particles collected from embryonated chicken eggs, to a hypotonic treatment, which comprises contacting the virus solution with a hypotonic aqueous solution of 160 mOsm/kg or less to lower the osmolarity of the virus solution;
- and
- prior to or after subjecting the virus solution to a hypotonic treatment, inactivating the virus.
Dependencies are inferred from the claim text.