Dual-scale porous silica particle-based composition for preventing or treating cancer
AssigneeResearch & Business Foundation Sungkyunkwan University
InventorsJae Yun Kim, Nguyen Thanh Loc
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Abstract
The present invention relates to a dual-scale porous silica particle-based pharmaceutical composition for preventing or treating cancer, which includes porous silica nanoparticles and porous silica microparticles. The pharmaceutical composition of the present invention promotes the generation of a larger amount of antigen-specific, cytotoxic T cells against cancer than a mesoporous silica nanoparticle (MSN) vaccine, and exhibits increased anti-tumor efficacy compared with a mesoporous silica microrod (MSR) vaccine.
Claims13
A method of preventing or treating cancer, the method comprising:
- administering a dual-scale porous silica particle-based pharmaceutical composition to a subject in need thereof,
- wherein the composition comprises:
- cancer-antigen- and negatively charged adjuvant-loaded positively charged porous silica nanoparticles, which are physically adsorbed onto surfaces of
- porous silica microparticles carrying a chemoattractant attracting dendritic cells (DCs).
Dependencies are inferred from the claim text.