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US 11,890,322 B2Granted
Methods for promoting wound healing and hair growth comprising GDNF administration
AssigneeThe Jackson Laboratory
InventorsRobert E. Braun, Manju Sharma
Life of this patent
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Abstract
The present invention generally relates to uses of glial cell line-derived growth factor (GDNF) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of GDNF, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein. The invention relates also to formulations and kits for achieving the indicated pharmaceutical advantages.
Claims18
A method for promoting hair growth comprising:
- administering to skin comprising hair follicles of a subject in need thereof a therapeutically effective dose of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF),
- wherein the therapeutically effective dose is 1-10 mg, 10-20 mg, 20-30 mg, or 30-40 mg, thereby promoting an increase in hair follicle number of the skin of the subject.
Dependencies are inferred from the claim text.