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US 11,890,320 B2Granted
CLEC11A is a bone growth agent
AssigneeBoard of Regents, The University of Texas System
InventorsSean Morrison, Rui Yue
Life of this patent
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Abstract
The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.
Claims10
A method of treating a bone trauma, disease or disorder treatable by enhancing bone formation, strength, volume, or density in a human subject, the method comprising:
- administering a human C-type Lectin Domain Containing 11A (CLEC11a) to the subject, wherein the human CLEC11a comprises the sequence of SEQ ID NO:
- 10;
- wherein the human CLEC11a is administered systemically or locally;
- wherein if the human CLEC11a is administered locally, it is administered to a site of the bone in need of treatment;
- and
- wherein the human subject suffers from a bone fracture, osteopenia, osteoporosis, periodontal disease, or is in need of a spinal fusion or a dental implant.
3 more elements
Dependencies are inferred from the claim text.