Antibody molecule-drug conjugates and uses thereof

An antibody molecule-drug conjugate (ADC) comprising an anti-LPS antibody molecule and a covalently coupled antimicrobial peptide, wherein the antibody molecule comprises one or more motifs, wherein:

• (I) the one or more motifs have the formula:
• X1(FGly′)X2Z2X3Z3
• wherein FGly′ is a 2-formylglycine residue, a cysteine, or a serine;
• Z2 is a proline or alanine residue;
• X1, X2, and X3 are each independently any amino acid;
• Z3 is a basic amino acid;
• and
• (II) the antibody molecule comprises:
• (i) a heavy chain comprising a heavy chain variable region (VH) comprising:
• (a) an HCDR1 comprising the amino acid sequence of SEQ ID NO:
• 108, an HCDR2 comprising the amino acid sequence of SEQ ID NO:
• 146, and an HCDR3 comprising the amino acid sequence of SEQ ID NO:
• 107;
• or
• (b) an HCDR1 comprising the amino acid sequence of SEQ ID NO:
• 105, an HCDR2 comprising the amino acid sequence of SEQ ID NO:
• 106, and an HCDR3 comprising the amino acid sequence of SEQ ID NO:
• 107;
• and/or
• (ii) a light chain comprising a light chain variable region (VL) comprising:
• an LCDR1 comprising the amino acid sequence of SEQ ID NO:
• 138, an LCDR2 comprising the amino acid sequence of SEQ ID NO:
• 142, and an LCDR3 comprising the amino acid sequence of any of SEQ ID NO:
• 112;
• and
• (III) the antimicrobial peptide comprises the amino acid sequence of GGGKFFRKLKKSVKKRAKEFFKKPRVIGVSIPF (SEQ ID NO:
• 156).