Back to results
US 11,890,318 B2Granted
Methods and compositions for modulating appetite and intake of sodium
AssigneeCalifornia Institute of Technology
InventorsYuki Oka, Sangjun Lee
Life of this patent
Estimating the term…
Abstract
Disclosed herein include methods and compositions for modulating sodium appetite and/or intake. In some embodiments, the sodium appetite of a subject is reduced. Also disclosed include methods for identifying modulators for sodium appetite and/or intake.
Claims6
A method of reducing sodium appetite in a subject in need thereof, the method comprising:
- inhibiting a plurality of prodynorphin (PDYN)-positive neurons in the pre-locus coeruleus (pre-LCPDYN neurons) of the subject, wherein inhibiting the plurality of pre-LCPDYN neurons of the subject comprises chemogenetically inhibiting the plurality of pre-LCPDYN neurons, thereby reducing sodium ingestion of the subject;
- and wherein sodium ingestion of the subject is reduced within 50 minutes or less relative to a subject wherein the pre-LCPDYN neurons have not been chemogenetically inhibited, following the chemogenetic inhibition of neurons in the pre-LC that express PDYN.
Dependencies are inferred from the claim text.