Cell-protecting composition containing cyclo histidine-proline as active ingredient
AssigneeNovmetapharma Co., Ltd.
InventorsHoe-Yune Jung, Heon-Jong Lee, Jong-Su Jeon, Yon-Su Kim, Seung-Hee Yang, Yong-Chul Kim, Jong-Joo Moon, Hwan-Soo Yoo, Kyeong-Mi Choi
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Abstract
A new use of a cyclo histidine-proline (Cyclo His-Pro, CHP) is disclosed. A composition including cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from damage and/or toxicity induced by various causes. The composition is useful and effective in protecting kidney and/or liver cells/tissues and in treating a subject with kidney and/or liver diseases and/or damages.
Claims14
A method of treating a subject suffering from a kidney disease or kidney damage,
- said method comprising administering an effective amount of a composition to the subject,
- wherein the composition comprises cyclo-histidine-proline (CHP) or a pharmaceutically acceptable salt thereof, as an active ingredient, and
- wherein the kidney disease or kidney damage excludes acute renal failure.
A method of inhibiting kidney cell apoptosis in a subject with kidney disease or kidney damage, comprising administering a composition to the subject in an amount effective to inhibit kidney cell apoptosis,
- wherein the composition comprises
- (a) cyclo histidine-proline (CHP) or its pharmaceutically acceptable salt, as an active ingredient, and
- (b) one or more additives selected from the group consisting of sodium starch glycolate, crospovidone, croscarmellose sodium, alginic acid, carboxymethylcellulose calcium, carboxymethylcellulose sodium, chitosan, guar gum, low-substituted hydroxypropylcellulose, magnesium aluminum silicate, polacrilin potassium, starch, gelatinized starch, microcrystalline cellulose, povidone, colloidal silicon dioxide, calcium hydrogen phosphate, lactose, mannitol, sugar, arabic gum, pregelatinized starch, corn starch, powdered cellulose, hydroxypropylcellulose, opadry, sodium starch glycolate, carnauba lead, synthetic aluminum silicate, stearic acid, magnesium stearate, aluminum stearate, calcium stearate, white sugar, dextrose, sorbitol, and talc, to the subject, and
- wherein the kidney disease or kidney damage is chronic.
Dependencies are inferred from the claim text.