Pharmaceutical composition and method of manufacturing

A process for obtaining a first extract of Cannabis sativa, Cannabis indica, or combination thereof, enriched with at least one of:

• cannabinol;
• cannabinolic acid;
• Δ(9)-tetrahydrocannabinolic acid;
• Δ(9)-cannabidiol;
• Δ(9)-tetrahydrocannabidiolic acid;
• Δ(8)-tetrahydrocannabinolic acid;
• Δ(8)-tetrahydrocannabidiol;
• Δ(8)-tetrahydrocannabidiolic acid;
• Δ(9)-tetrahydrocannabivarin;
• cannabigerol;
• cannabigerolic acid;
• cannabichromene;
• cannabichromenic acid;
• cannabicyclol;
• and cannabicyclolic acid, and
• a second extract of Cannabis sativa, Cannabis indica, or combination thereof, enriched with at least one of Δ(8)-tetrahydrocannabinol and Δ(9)-tetrahydrocannabinol, the process comprising:
• (a) contacting Cannabis sativa, Cannabis indica, or a combination thereof, with carbon dioxide as the sole supercritical fluid solvent, at a pressure of 1,400 psi to 3,800 psi, at a temperature of 35° C. to 65° C., for a period of time of 1.5 hours to 8.5 hours, to provide an enriched extract of Cannabis sativa, Cannabis indica, or combination thereof;
• and
• (b) removing the supercritical carbon dioxide from the extract;
• wherein the (a) contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide and then the (b) removing the supercritical carbon dioxide, is carried out two or more times, such that the process is a supercritical carbon dioxide fluid extraction;
• wherein a first supercritical carbon dioxide fluid extraction is carried out such that:
• (i) the contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide, is carried out at a pressure of 1,600 psi to 2,000 psi, at a temperature of 44° C. to 54° C., for a period of time of 1.5 hours to 4.5 hours, to provide the first extract;
• wherein a second supercritical carbon dioxide fluid extraction is carried out such that:
• (i) the contacting of the Cannabis sativa, Cannabis indica, or a combination thereof, with the supercritical carbon dioxide, is carried out at a pressure of 2,250 psi to 3,800 psi, at a temperature of 44° C. to 54° C., for a period of time of 3.5 hours to 8.5 hours, to provide a second extract.