Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
AssigneeFinch Therapeutics Holdings LLC
InventorThomas Julius Borody
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Abstract
The present disclosure provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments; and methods for making and using them. Methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection.
Claims19
A pharmaceutical composition comprising saline, a cryoprotectant and a microbiota of a stool sample comprising anaerobic bacteria, wherein particular bacterial species have not been pre-segregated from the microbiota, wherein the pharmaceutical composition is formulated for administration to a subject by enema through flexible tubing, wherein the pharmaceutical composition is contained in a container configured to provide a reduced oxygen environment to preserve the anaerobic bacteria.
Dependencies are inferred from the claim text.