Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same
AssigneeFinch Therapeutics Holdings LLC
InventorBharat Dixit
Life of this patent
Estimating the term…
Abstract
This application provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments, and methods for making, storing and using them, including formulations that effectively preserve microbial cell viability during freeze-thaw or freeze-drying. Compositions provided herein are useful for treating various diseases or conditions such as autism spectrum disorder, Crohn's Disease, ulcerative colitis, irritable bowel syndrome, and recurrent or primary C. difficile infection.
Claims17
A pharmaceutical composition comprising a lyophilized fecal microbe preparation comprising microbial cells derived from a healthy human donor and a lyophilization formulation, wherein, prior to lyophilization, said lyophilization formulation comprises between about 12.5% and about 60% trehalose and between about 0.005% and about 0.08% cysteine.
Dependencies are inferred from the claim text.