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US 11,890,302 B2Granted
Gamma delta CAR-T cells comprising Fc gamma intracellular signaling domains
AssigneeTC Biopharm LTD
InventorsAgapitos Patakas, Timothy London, Emilio Cosimo
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Abstract
The present invention relates to gamma delta (γδ) T cells and/or Natural Killer (NK) cells expressing constructs to provide for the expression of a Chimeric Antigen Receptor (CAR) incorporating the signalling domain of FCY Receptors. Suitably the invention also relates to constructs to provide such CARs and methods for introducing such CARs into cells and expressing such CARs in cells comprising receptors of gamma delta (γδ) T cells and/or Natural Killer (NK) cells.
Claims7
A gamma delta T cell comprising a nucleic acid construct to provide for expression of a CAR comprising:
- (i) an antigen-binding domain coupled to a trans-membrane domain, and
- (ii) an intracellular activation signalling domain
- wherein the intracellular signalling domain consists of one or more Fcγ Receptor intracellular signalling domains, wherein the one or more Fcγ Receptor intracellular signalling domains is from an Fc R common gamma chain, a CD16, a CD32a, a CD32c, or a CD64, and wherein binding of antigen to the antigen binding domain of the CAR causes signalling by the intracellular signalling domain of the CAR.
Dependencies are inferred from the claim text.