Back to results
US 11,890,300 B2Granted
Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor
AssigneeMiltenyi Biotec GmbH
InventorsDominik Lock, Mario Assenmacher, Andrew Kaiser
Life of this patent
Estimating the term…
Abstract
The present invention provides an immune effector cell that comprises a chimeric antigen receptor (CAR) specific for a tag of a tagged polypeptide, wherein said polypeptide binds to an antigen of a target cell, and a chimeric costimulatory receptor (CCR) specific for a further antigen. The CCR is not able to mediate said immune response on its own but boosts the immune response of said immune effector cell triggered by the CAR.
Claims10
A T cell comprising:
- a) a chimeric antigen receptor (CAR) comprising a first antigen binding domain, a first transmembrane domain and a first cytoplasmic signaling domain comprising at least one CD3ζ cytoplasmic signaling domain and at least one 4-1BB co-stimulatory signaling domain, wherein said first antigen binding domain binds to a tag of a tagged polypeptide, and wherein the polypeptide of said tagged polypeptide binds to an antigen expressed on the surface of a target cell to be killed;
- and
- b) a chimeric costimulatory receptor (CCR) comprising a second antigen binding domain, a second transmembrane domain and a second cytoplasmic part comprising at least one CD28 co-stimulatory domain and/or at least one 4-1BB co-stimulatory domain or a combination thereof, wherein said CCR does not comprise CD3ζ, and wherein said second antigen binding domain binds to a further antigen, and wherein said further antigen is not expressed on the surface of said target cell.
Dependencies are inferred from the claim text.