Helicobacter pylori eradication method including step for orally administering composition including complex of non-absorbable antibiotic and clay mineral to subject
AssigneeKorea Institute of Geoscience and Mineral Resources
InventorsJae-Hwan Kim, Il-Mo Kang, Young-Goo Song, Ki-Min Roh, Yun-Goo Song, Sung-Man Seo, Dae-Young Kim
Life of this patent
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Abstract
The present application relates to an orally administered pharmaceutical composition or kit for eradicating Helicobacter pylori, including a complex of a non-absorbable antibiotic and a clay mineral. The pharmaceutical composition and kit of the present invention may further include a β-lactam antibiotic and/or a gastric acid inhibitor.
Claims4
An orally administered pharmaceutical composition for eradicating clarithromycin-resistant Helicobacter pylori, comprising a β-lactam antibiotic, and a gastric acid inhibitor, and a complex of a non-absorbable antibiotic with clay mineral,
- wherein the non-absorbable antibiotic is selected from the group consisting of gentamicin and netilmicin at an effective amount that eradicates the clarithromycin-resistant Helicobacter pylori and decreases damage of the surface epithelium, inflammatory cell infiltration, and/or submucosal edema, and
- wherein the clay mineral is selected from the group consisting of montmorillonite, bentonite, beidellite, nontronite, saponite, and hectorite.
An orally administered kit for eradicating clarithromycin-resistant Helicobacter pylori, comprising a β-lactam antibiotic, a gastric acid inhibitor, and a complex of a non-absorbable antibiotic and a clay mineral,
- wherein the non-absorbable antibiotic is selected from the group consisting of gentamicin and netilmicin at an effective amount that eradicates the clarithromycin-resistant Helicobacter pylori and decreases damage of the surface epithelium, inflammatory cell infiltration, and/or submucosal edema, and
- wherein the clay mineral is selected from the group consisting of montmorillonite, bentonite, beidellite, nontronite, saponite, and hectorite.
Dependencies are inferred from the claim text.