Skin barrier composition
AssigneeHyphens Pharma Pte. Ltd.
InventorsKevin Hammond, Adrian Davis
Life of this patent
Estimating the term…
Abstract
The present invention provides a composition for topical administration of a polyhydroxy acid, such as lactobionate and especially zinc lactobionate, and low pH to an external body surface such as skin. The composition is designed to be highly effective in delivering low pH and zinc lactobionate across the layers of the skin to more effectively treat and prevent skin conditions involving a defective skin barrier such as eczema and severe dry skin.
Claims30
A method of treating or reducing likelihood of a condition caused by a defective skin barrier or for promoting skin barrier repair, wherein the condition is selected from the group consisting of eczema, atopic eczema, dermatitis, atopic dermatitis, non-atopic eczema, non-atopic dermatitis, seborrheic eczema, irritant contact dermatitis, allergic contact dermatitis, asteatotic eczema, pruritis, acne, dry skin and sensitive skin, the method comprising topical application of a composition to an external body surface of a subject who is affected by, or is at risk of being affected by, said condition or who is in need of skin barrier repair;
- wherein the composition comprises:
- a polyhdroxy acid and a zinc salt of its conjugate base, wherein the polyhydroxy acid is selected from the group consisting of lactobionic acid, gluconolactone, a combination of lactobionic acid and gluconolactone, and derivatives thereof;
- a partition coefficient enhancer selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,5 pentane diol, and combinations thereof, wherein the partition coefficient enhancer is at 15-30% w/w of the composition;
- and
- a diffusion coefficient enhancer which is selected from a C12 to C14 straight chain fatty acid or a C14 straight chain primary alcohol, wherein the diffusion coefficient enhancer is at 1.0-2.0% w/w of the composition;
- and
- wherein the composition has a pH in the range consisting of 2.7 to 5.0.
A method of treating or reducing likelihood of a condition caused by a defective skin barrier or for promoting skin barrier repair, wherein the condition is selected from the group consisting of eczema, atopic eczema, dermatitis, atopic dermatitis, non-atopic eczema, non-atopic dermatitis, seborrheic eczema, irritant contact dermatitis, allergic contact dermatitis, asteatotic eczema, pruritis, acne, dry skin and sensitive skin, the method comprising topical application of a composition to an external body surface of a subject who is affected by, or is at risk of being affected by, said condition or who is in need of skin barrier repair;
- wherein the composition comprises:
- an aqueous-glycol phase comprising:
- a polyhydroxy acid and a zinc salt of its conjugate base at 4.0-6.0% w/w, wherein the polyhydroxy acid is selected from the group consisting of lactobionic acid, gluconolactone (gluconic acid), a combination of lactobionic acid and gluconolactone (gluconic acid), and derivatives thereof;
- a partition coefficient enhancer selected from the group consisting of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,5 pentane diol, propylene carbonate, dipropylene glycol, diethylene glycol monoethyl ether, N-methyl pyrrolidone and a combination thereof at 18.0-22.0% w/w;
- and
- water;
- and
- an oil phase comprising:
- a diffusion coefficient enhancer which is a C12 to C14 straight chain fatty acid or a C14 straight chain primary alcohol at 1.0-2.0% w/w;
- a second agent as emollient;
- and
- a third agent as surfactant;
- wherein % w/w is based on the composition, and wherein the composition has a pH in the range consisting of 3.0 to 3.5.
Dependencies are inferred from the claim text.