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AssigneeInnova Agri Bio Park Private Limited
InventorsKrishna Murthy Ella, Kankanallu Shankaranarayana Ravi
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Nanogel and nanoparticles comprising vitamin D encapsulated in agar-agar and a polymer selected from poly(acrylamidoglycolic acid) and pectin are provided. Also provided is aqueous nanogel compositions which can be used for prevention or treatment of vitamin D deficiency and methods for encapsulating vitamin D in nanogels and nanoparticles. The nanogel and nanoparticles and compositions thereof are cost-effective, have a considerable shelf life, a faster rate of absorption in the body leading to faster bioavailability. Further, the nanogels and nanoparticles are made with vegetarian sources and causes no changes in the organoleptic properties. The Vitamin D nanogels and nanoparticles developed can be used for fortification of any food, aqueous medium or beverage, including bottled drinking water.
A hydrophilic nanoparticle encapsulating Vitamin D, wherein the hydrophilic nanoparticle is selected from the group consisting of nanogel or PLGA nanoparticle, and wherein the Vitamin D is present in an amount of 5 to 8 wt % of the nanogel or the Vitamin D is present in an amount of 2 to 4 wt % of the PLGA nanoparticle, dispersed in a medium.
The hydrophilic nanoparticle encapsulating Vitamin D as claimed in 2, wherein agar-agar is present in an amount of 30 to 35 wt % of the nanogel.
The hydrophilic nanoparticle encapsulating Vitamin D as claimed 2, wherein the polymer is present in an amount of 45 to 50 wt % of the nanogel.
The hydrophilic nanoparticle encapsulating Vitamin D as claimed 1, wherein the concentration of nanogels dispersed in the medium is in the range from 0.15 mg/L to 0.45 mg/L.
The hydrophilic nanoparticle encapsulating Vitamin D as 1, wherein Vitamin D is cholecalciferol.
The hydrophilic nanoparticle encapsulating Vitamin D as claimed 1, wherein the concentration of the PLGA nanoparticle is 0.35 mg/L to 1 mg/L.
The hydrophilic nanoparticle encapsulating Vitamin D as claimed 1, wherein the medium is an aqueous medium.
A method for preparation of encapsulated Vitamin D nanogels, comprising:
A method for preparation of encapsulated Vitamin D PLGA nanoparticles, comprising:
Dependencies are inferred from the claim text.