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US 11,890,287 B2Granted
Therapeutic compounds and compositions for treating social disorders and substance use disorders
AssigneeKinoxis Therapeutics Pty Ltd
InventorsIain Stewart McGregor, Michael Kassiou, Michael Thomas Bowen, Callum Hicks, William Jorgensen
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Abstract
Disclosed herein are compounds, compositions and methods for the treatment of neurological, psychiatric disorders which are characterized by a fundamental disruption of social behaviour, and substance use disorders. In particular, disclosed herein are compounds of Formula (I), or salts or prodrugs thereof. Methods of treating or preventing neurological, psychiatric disorders and substance use disorders, using compounds of Formula (I), or salts and prodrugs are also disclosed.
Claims18
A method of treating a substance abuse disorder in a subject,
- wherein the substance abuse disorder relates to a drug or chemical substance selected from cocaine, opiates, amphetamines, heroin, alcohol and nicotine,
- the method comprising administering to a subject in need thereof an effective amount of a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:
- wherein:
- Z is selected from:
- NH;
- R1 is selected from H or C(O)R4;
- R2 is selected from:
- H, OH, a halogen, an optionally substituted C1-5 alkyl, or an optionally substituted OC1-5 alkyl;
- R3 is selected from:
- H, OH, a halogen, an optionally substituted C1-5 alkyl, or an optionally substituted OC1-5 alkyl;
- and
- R4 is an optionally substituted C1-5 alkyl.
9 more elements
Dependencies are inferred from the claim text.