Migraine prevention and treatment
AssigneeUniversitäTs-Kinderspital Beider Basel
InventorsElena Gross, Dirk Fischer
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Abstract
The invention relates to a compound for use in a method of treatment or prevention of migraine and/or symptoms thereof. The compound is selected from beta-hydroxybutyric acid (βHB) or a pharmaceutically acceptable salt thereof, acetoacetate (AcAc) or a pharmaceutically acceptable salt thereof, a metabolic precursor of βHB or AcAc 1,3-butanedio and a compound comprising an acetoacetyl- or 3-hydroxybutyrate moiety. The invention further relates to a pharmaceutical composition comprising βHB, AcAc or a pharmaceutically acceptable salt thereof.
Claims22
A method of treatment or prevention of migraine and/or symptoms thereof in a patient in need thereof, said method comprising administering to the patient a compound which is a metabolic precursor of βHB selected from the group consisting of
- (i) a pharmaceutically acceptable ester of beta-hydroxybutyrate (βHB),
- (ii) a pharmaceutically acceptable ester of acetoacetate (AcAc),
- (iii) a compound comprising an acetoacetyl- or 3-hydroxybutyrate moiety,
- (iv) a keto ester,
- (v) a middle chain triglyceride (MCT), and
- (vi) a pharmaceutically acceptable salt of any one of (i) to (v).
Dependencies are inferred from the claim text.