# US 11,890,260 B2 · Compositions for treating acne and dermatological conditions

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- Number: US 11,890,260 B2
- Document ID: US11890260B2
- Status: Granted
- Kind: B2
- Application number: 17/385,454
- Filed: 2021-07-26
- Published: 2021-11-25
- Granted: 2024-02-06
- Earliest claimed: 2020-05-22
- Assignees: Ilera Derm LLC
- Applicants: Ilera Derm LLC
- Inventors: Brian Warrington; Karyn Grossman; Oludare Odumosu; Zoltan Kerekes
- Web page: https://patentgrep.com/patent/US11890260B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 8/347: {Phenols}
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/37: Coumarins, e.g. psoralen
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 31/60: Salicylic acid; Derivatives thereof
- A61P 17/10: Anti-acne agents
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/008: {Preparations for oily skin}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present disclosure generally relates to compositions comprising unique combinations of cannabinoids, antioxidants, and cofactors. The present disclosure also provides methods of making the compositions and methods for using the compositions for the treatment of mitochondrial ATP deficit disorders.

## Claims

### Claim 1

A composition, comprising:
(a) between 3-30 μM cannabidiol (CBD);
(b) between 4-40 μM niacinamide; and
(c) between 30-100 μM urolithin A.

### Claim 2 (depends on 1)

The composition of claim 1, further comprising an antioxidant.

### Claim 3 (depends on 1)

A method for increasing ATP metabolism in a cell comprising applying the composition of claim 1 to skin of a patient.

### Claim 4 (depends on 2)

The composition of claim 2, wherein the antioxidant is L-ergothioneine.

### Claim 5 (depends on 3)

The method of claim 3, wherein the skin of the patient exhibits acne.