Devices and methods for slurry generation

An apparatus for delivery of a cold slurry, the apparatus comprising:

• a cylindrical member comprising:
• a first end, a second end, and a longitudinal axis extending through the first and second ends;
• an outer surface extending between the first and second ends along the longitudinal axis;
• and
• an interior lumen defined by an interior wall of the cylindrical member, the interior lumen configured to receive and hold a cold slurry;
• a plunger at least partially disposed within the interior lumen and configured to move within the cylindrical member in the direction of the longitudinal axis, and the plunger comprising a head, a plunging member, and a rod extending between the head and the plunging member along the longitudinal axis of the cylindrical member,
• at least one needle extending from the second end of the cylindrical member,
• a cooling sleeve surrounding at least a portion of the cylindrical member, the cooling sleeve being configured to cool or maintain a temperature of the cold slurry within the interior lumen of the cylindrical member,
• a removable cap on the cooling sleeve for closure of the cooling sleeve;
• and
• an agitation device comprising least one rotation blade extending from the plunging member towards the second end of the cylindrical member;
• and
• wherein the agitation device is configured to agitate the cold slurry upon rotation of the plunger.

An apparatus for delivery of a cold slurry, the apparatus comprising:

• a cylindrical member comprising:
• a first end, a second end, and a longitudinal axis extending through the first and second ends;
• an outer surface extending between the first and second ends along the longitudinal axis;
• and
• an interior lumen defined by an interior wall of the cylindrical member, the interior lumen configured to receive and hold a cold slurry;
• a plunger at least partially disposed within the interior lumen and configured to move within the cylindrical member in the direction of the longitudinal axis, and the plunger comprising a head, a plunging member, and a rod extending between the head and the plunging member along the longitudinal axis of the cylindrical member,
• at least one needle extending from the second end of the cylindrical member,
• a cooling sleeve surrounding at least a portion of the cylindrical member, the cooling sleeve being configured to cool or maintain a temperature of the cold slurry within the interior lumen of the cylindrical member, and
• a removable cap on the cooling sleeve for closure of the cooling sleeve;
• wherein the cap is configured to engage with and rotate the plunger of the cylindrical member.

An apparatus for delivery of a cold slurry, the apparatus comprising:

• a cylindrical member comprising:
• a first end, a second end, and a longitudinal axis extending through the first and second ends;
• an outer surface extending between the first and second ends along the longitudinal axis;
• an interior lumen defined by an interior wall of the cylindrical member, the interior lumen configured to receive and hold a cold slurry;
• a plunger at least partially disposed within the interior lumen and configured to move within the cylindrical member in the direction of the longitudinal axis, and the plunger comprising a head, a plunging member, and a rod extending between the head and the plunging member along the longitudinal axis of the cylindrical member;
• at least one needle extending from the second end of the cylindrical member;
• a cooling sleeve surrounding at least a portion of the cylindrical member, the cooling sleeve being configured to cool or maintain a temperature of the cold slurry within the interior lumen of the cylindrical member, the cooling sleeve and the cylindrical member being arranged concentrically with a space formed between an inner surface of the cooling sleeve and the outer surface of the cylindrical member, the space between the cylindrical member and the cooling sleeve forming a chamber;
• a container surrounding at least a portion of the cooling sleeve and fluidically connected to the chamber, the container configured to hold a cooling fluid and supply the cooling fluid to the chamber;
• at least one inlet located between the chamber and the container configured to allow the cooling fluid to flow from the container and into the chamber;
• a conductive membrane provided between the chamber and the outer surface of the cylindrical member.