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US 11,887,828 B2Granted
Determination of antidepressants by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsAnita Dermartirosian, Edith Shahbol, Karin Thomassian, Shaun Rezaei, Asad Shah
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Abstract
Methods are described for detecting or determining the amount of antidepressants and/or antidepressant metabolites in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying antidepressants and/or antidepressant metabolites in a sample.
Claims16
A method for detecting or determining the amount of one or more selective serotonin reuptake inhibitors (SSRI) and SSRI metabolites in a sample by tandem mass spectrometry, said method comprising:
- a. subjecting the sample to ionization under conditions suitable to produce one or more ions detectable by mass spectrometry;
- b. determining the amount of one or more ions by tandem mass spectrometry, wherein the one or more ions comprise a fluoxetine fragment ion with a mass/charge ratio of 148.1±0.2 and a norfluoxetine fragment ion with a mass/charge ratio of 134.2±0.2 or 30.1±0.2;
- and
- c. using the amount of the one or more ions determined in step (b) to determine the amount of SSRI and SSRI metabolites comprising fluoxetine and norfluoxetine in the sample.
1 more element
Dependencies are inferred from the claim text.