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US 11,885,780 B2Granted
Methods for detecting chromogranin a by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsDarren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Abstract
Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
Claims21
A method for determining the amount of chromogranin A (CgA) in a sample, said method comprising:
- (a) purifying CgA in the sample;
- (b) ionizing CgA to produce one or more ion(s) of CgA detectable by mass spectrometry;
- (c) determining the amount of the ion(s) from step (b) by mass spectrometry, comprising measuring the amount of a precursor ion having a mass-to-charge ratio of 729.6±0.5, wherein the amount of ions is related to the amount of CgA in the sample, wherein the limit of quantitation of the method is less than or equal to 50 ng/mL, and
- (d) correlating the amount of CgA in the sample to the amount of the precursor ion measured in step (c).
1 more element
Dependencies are inferred from the claim text.