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US 11,884,984 B2Granted
Kits and methods for assessing a condition or a risk of developing a condition, and related methods of treatment
AssigneeFred Hutchinson Cancer Research Center
InventorsSujatha Srinivasan, David N. Fredricks
Life of this patent
Estimating the term…
Abstract
Provided herein are kits and methods for detecting, monitoring, and classifying a nongonococcal urethritis (NGU) infection in a male subject based on a genitourinary microbiome of a subject, as well as related methods of treating. Also provided are kits and methods for classifying a risk of human immunodeficiency virus (HIV) infection in a subject based on a genitourinary microbiome of a subject, as well as related methods of preventing infection.
Claims16
A method for
- detecting and classifying a nongonococcal urethritis (NGU) infection in a male subject, the method comprising
- detecting a pathogen in a urethral sample from the male subject, wherein the pathogen comprises Haemophilus influenzae, Mycoplasma penetrans, or both, wherein detecting the pathogen comprises carrying out a quantitative PCR on the urethral sample with a primer set that hybridizes to nucleotide sequences selected from a 16S rRNA gene of Haemophilus influenzae or Mycoplasma penetrans to generate Haemophilus influenzae and/or Mycoplasma penetrans specific amplicons, and
- classifying the NGU infection based at least in part on detection of the pathogen higher than a baseline level of a reference from healthy individuals.
Dependencies are inferred from the claim text.