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US 11,884,982 B2Granted
Tumor marker, methylation detection reagent, kit and use thereof
AssigneeCreative Biosciences (Guangzhou) Co., Ltd.
InventorsXianglin Liu, Rongsong Zhao, Hongzhi Zou
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Abstract
The present invention relates to the technical field of biology. Disclosed are a tumor marker, a methylation detection reagent, a kit and application thereof. Disclosed in the present invention is that: a colorectal cancer specimen can be distinguished from a fecal specimen of a normal person by detection a methylation level of COL4A1 gene promoter region. The present invention relates to detecting colorectal cancer by using the methylation detection reagent of the gene.
Claims14
A methylation detection kit of COL4A1 gene, comprising:
- a gene capturing reagent comprising a magnetic bead probe complex;
- a capture sequence having a nucleotide sequence having at least 85% identity to SEQ ID NO:
- 1;
- a first primer having a nucleotide sequence having at least 85% identity to SEQ ID NO:
- 2;
- a second primer having a nucleotide sequence having at least 85% identity to SEQ ID NO:
- 3;
- and
- a probe having a nucleotide sequence having at least 85% identity to SEQ ID NO:
- 4.
7 more elements
Dependencies are inferred from the claim text.