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US 11,884,952 B2Granted
Daptomycin-producing Streptomyces strain and use thereof
AssigneeZhejiang University
InventorsYongquan Li, Jiaole Fang, Xuming Mao, Xinai Chen
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AssigneeZhejiang University
InventorsYongquan Li, Jiaole Fang, Xuming Mao, Xinai Chen
Estimating the term…
The present invention provides a novel daptomycin-producing Streptomyces strain and use thereof, the strain is a subspecies of streptomyces griseus, named Streptomyces griseus L340, and the preservation number is CGMCC17921. The genetic character and fermentation unit of the strain provided by the present invention are relatively stable, the culture and fermentation conditions are suitable for industrial production of daptomycin, and the interference of pigment in later separation and purification is eliminated. The secondary metabolite daptomycin is obtained through fermentation of the Streptomyces provided by the present invention, which has the advantages of no interference of pigment accumulation, cleaner metabolic spectrum and thus is obviously superior in later separation and purification.
A novel daptomycin-producing Streptomyces strain, wherein the Streptomyces strain is classified and named as Streptomyces griseus L340 preserved in China General Microbiological Culture Collection Center with a preservation date of Jun. 12, 2019 and a preservation number of CGMCC No. 17921, and the strain is kept in a media with a buffer to maintain the pH 5-11.
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