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AssigneeMemorial Sloan Kettering Cancer Center
InventorsLiang Deng, Stewart Shuman, Ning Yang, Taha Merghoub, Jedd Wolchok
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Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of poxviruses, including a recombinant modified vaccinia Ankara (MVA) virus or vaccinia virus with deletion of vaccinia host-range factor C7 (MVAΔC7L and VACVΔC7L, respectively), alone or in combination with immune checkpoint blocking agents, as an oncolytic and immunotherapeutic composition. In some embodiments, the technology of the present disclosure relates to a MVAΔC7L or VACVΔC7L virus further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L).
An engineered modified vaccinia Ankara (MVA) virus strain comprising a disruption of a C7L gene and a nucleotide sequence encoding human Fms-like tyrosine kinase 3 ligand (hFlt3L).
An engineered attenuated vaccinia virus (VACV) strain comprising a disruption of a C7L gene.
A recombinant vaccinia virus (VACV) nucleic acid sequence, wherein the nucleic acid sequence between position 15,716 and 16,168 of SEQ ID NO:
Dependencies are inferred from the claim text.