Back to results
US 11,884,926 B2Granted
Campaign-ready series of recombinant adeno-associated virus (rAAV) complementing plasmids
AssigneeUniversity of Massachusetts
InventorsTerence Flotte, Qiushi Tang, Allison Keeler-Klunk, Qin Su
Life of this patent
Estimating the term…
Abstract
In some aspects, the disclosure relates to compositions and methods for production of recombinant adeno-associated virus (rAAV) particles. The disclosure is based, in part, on isolated nucleic acids and systems that include only two vectors and are suitable for production of multiple different single gene viral vectors in a multiple small-scale campaign mode (e.g., 1013 to 1016 viral particles.)
Claims18
A recombinant adeno-associated virus (rAAV) production system comprising:
- (i) a first vector comprising the nucleic acid sequence set forth in any one of SEQ ID NOs:
- 1-9;
- and,
- (ii) a second vector comprising one or more nucleic acids encoding an expression cassette comprising a transgene flanked by adeno-associated virus inverted terminal repeat (ITR) sequences.
1 more element
An isolated nucleic acid comprising the sequence set forth in any one of SEQ ID NOs:
- 1-9.
Dependencies are inferred from the claim text.