Body fluid resistant tissue adhesives
AssigneesMassachusetts Institute of Technology, Mayo Foundation for Medical Education and Research
InventorsXuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
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Abstract
A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
Claims16
An adhesive material for adhering one or more fluid covered surfaces comprising:
- a hydrophobic matrix;
- and
- a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix, the bioadhesive microparticles comprising:
- (i) one or more hydrophilic polymers or copolymers;
- (ii) one or more amine coupling groups, and
- (iii) one or more cross linkers,
- the hydrophobic matrix forming a protective matrix around the dispersed bioadhesive microparticles that protects the bioadhesive microparticles from the fluid, wherein disposing the adhesive material directly on the fluid covered surface and applying pressure to the adhesive material causes (a) the hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
Dependencies are inferred from the claim text.