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US 11,884,749 B2Granted
Compositions and methods for treating endometriosis
AssigneeEndoMet Biosciences, Inc.
InventorsTanya Petrossian, Stephen Fiacco, Tristin Rose, Amanda Hardy, Keerthi Boddupally, Matthew Willmore
Life of this patent
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Abstract
Provided herein are peptides that bind β-catenin, and compositions comprising said peptides. Peptides binding β-catenin prevent translocation to the nucleus and modulate the canonical Wnt pathway. Also provided herein are methods of using said peptides and compositions in the treatment of tissue-infiltrating conditions including endometriosis.
Claims18
A peptide comprising an amino acid sequence having the formula X1—X2—X3—X4—X5—X6—X7—X8—X9—X10—X11—X12—X13—X14—X15—-X16 (SEQ ID NO:
- 504), wherein:
- X1 is M;
- X2 is S;
- X3 is R;
- X4 is K or R;
- X5 is M;
- X6 is W;
- X7 is F;
- X8 is L;
- X9 is L;
- X10 is C;
- X11 is F;
- X12 is W;
- and
- X13 is G.
12 more elements
Dependencies are inferred from the claim text.