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US 11,884,745 B2Granted
Method of removing lipopeptides from solutions and changing their structure
AssigneeInventionbio Sp. Z O. O.
InventorsHanna Faltynowicz, Marek Kulazynski, Marcin Lukaszewicz
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Abstract
The present invention is a method for removing lipopeptides from solutions and changing their structure from cyclic to linear. The lipopeptide capture and sequestration takes place from solutions containing water through sorption. In the case of cyclic lipopeptides, in which the peptide ring is closed by a lactone bond, sorption is additionally associated with hydrolysis reactions occurring on the surface of active carbon, leading to linearization as a result of breaking the lactone bond.
Claims9
A method for lipopeptides, the method comprising the steps of:
- mixing an aqueous solution of cyclic lipopeptides with activated carbon, said cyclic lipopeptides having a peptide ring closed by a lactone bond, so as to form a suspension;
- adsorbing a portion of said cyclic lipopeptides on a surface of said activated carbon so as to form adsorbed cyclic lipopeptides;
- hydrolyzing another portion of said cyclic lipopeptides on said surface of said activated carbon so as to break said lactone bond and form linear lipopeptides at a percentage at least or above 83% of total lipopeptides in said suspension;
- separating said activated carbon from said suspension,
- wherein said activated carbon has a surface area above 600 m2/g, and wherein said aqueous solution is basic and has a pH at or above 9.71;
- and
- harvesting said linear lipopeptides from said suspension.
4 more elements
Dependencies are inferred from the claim text.