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US 11,884,736 B2Granted
Antibodies which bind to glucagon-like peptide 1 receptor (GLP1R)
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsHaruka Okamoto, Jee H. Kim
Life of this patent
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AssigneeRegeneron Pharmaceuticals, Inc.
InventorsHaruka Okamoto, Jee H. Kim
Estimating the term…
The present disclosure relates to antibodies or antigen-binding fragments thereof that bind specifically to the glucagon-like peptide 1 receptor (GLP1R) protein, and methods of use thereof. In various embodiments, the antibodies or antigen-binding fragments thereof are fully human antibodies that bind to GLP1R. In some embodiments, the antibodies or antigen-binding fragments thereof are useful for attenuating GLP1R activity, thus providing a means of treating, preventing, or alleviating a disease, disorder or condition associated with GLP1R in humans. In some embodiments, the antibodies or antigen-binding fragments thereof elevate glucose levels when administered to a subject and thereby treat hypoglycemia, such as post-bariatric hypoglycemia (PBH), by attenuating insulin secretion from pancreatic beta cells and decreasing insulin expression.
An antibody or antigen-binding fragment thereof that binds specifically to glucagon-like peptide 1 receptor, comprising:
An isolated antibody or antigen-binding fragment thereof that binds to the same epitope as an antibody or antigen-binding fragment thereof comprising a heavy chain/light chain comprising amino acid sequences of SEQ ID NOs:
An isolated antibody or antigen-binding fragment thereof that binds specifically to glucagon-like peptide 1 receptor comprising a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:
An isolated antibody or antigen-binding fragment thereof that binds specifically to glucagon-like peptide 1 receptor comprising a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:
An isolated antibody or antigen-binding fragment thereof that binds specifically to glucagon-like peptide 1 receptor comprising a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:
Dependencies are inferred from the claim text.