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US 11,884,732 B2Granted
Proteins binding HER2, NKG2D and CD16
AssigneeDragonfly Therapeutics, Inc.
InventorsGregory P. Chang, Ann F. Cheung, William Haney, Bradley M. Lunde, Bianka Prinz
Life of this patent
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Abstract
Multi-specific binding proteins that bind HER2, the NKG2D receptor, and CD 16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
Claims15
A protein comprising:
- (a) a first antigen-binding site that binds NKG2D;
- (b) a second antigen-binding site that binds HER2;
- and
- (c) a first antibody Fc domain of human IgG1 or a portion thereof and a second antibody Fc domain of human IgG1 or a portion thereof that together are sufficient to bind CD16, wherein the first antibody Fc domain or the portion thereof and the second antibody Fc domain or the portion thereof comprise different amino acid mutations to promote heterodimerization,
- wherein the first antigen-binding site comprises a heavy chain variable domain comprising the amino acid sequence of SEQ ID NO:1 and a light chain variable domain comprising the amino acid sequence of SEQ ID NO:2.
2 more elements
Dependencies are inferred from the claim text.