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US 11,884,730 B2Granted
Methods of sensitizing cancer to immunotherapy
AssigneeCase Western Reserve University
InventorsAlex Yee-Chen Huang, Agne Petrosiute
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Abstract
A method of sensitizing cancer to immunotherapy in a subject in need thereof includes administering to the subject a therapeutically effective amount of a CdK5 inhibitor to suppress immune checkpoint PD-L1.
Claims6
A method of inhibiting Interferon-y (IFN-y) induced Programmed Death-Ligand 1 (PD-L1) expression in medulloblastoma or rhabdomyosarcoma cancer cells of a subject, the method comprising:
- detecting the expression level of Cdk5 in the medulloblastoma or rhabdomyosarcoma cancer cells prior to administration of the Cdk5 inhibitor;
- comparing the detected expression level of Cdk5 to a threshold level;
- and
- administering to IFN-y induced PD-L1 overexpressing cancer cells of the subject an amount of a CdK5 inhibitor effective to suppress immune checkpoint PD-L1 expression in the medulloblastoma or rhabdomyosarcoma cancer cells and to enhance an immune response to the medulloblastoma or rhabdomyosarcoma cancer cells if the detected expression level of Cdk5 exceeds the threshold level.
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Dependencies are inferred from the claim text.