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US 11,884,724 B2Granted
Anti-PD-L1 antibodies and uses thereof
AssigneeMerck Patent GmbH
InventorsHoracio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
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Abstract
The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.
Claims14
An isolated anti-PD-L1 antibody or antigen binding fragment thereof comprising:
- (a) a heavy chain variable region;
- and
- (b) a light chain variable region
- comprising HVR-L1, HVR-L2 and HVR-L3 sequences,
- wherein:
- (i) the HVR-L1 sequence is TGTX7X8DVGX9YNYVS (SEQ ID NO:
- 8);
- and
- (ii) the HVR-L3 sequence is SSX13TX14X15X16X17RV (SEQ ID NO:
- 10);
- and
- wherein X7 is N or S;
- X8 is T, R or S;
- X9 is A or G;
- X13 is F or Y;
- X14 is N or S;
- X15 is R, T or S;
- X16 is G or S;
- and X17 is I or T.
16 more elements
Dependencies are inferred from the claim text.