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US 11,884,711 B2Granted
Fusion proteins of GDF15 and use thereof
AssigneeBeijing Ql Biopharmaceutical Co., Ltd.
InventorsYuanyuan Zhang, Wei Guo, Xinyu Zhao, Haixia Zou, Yaoguang Jin, Xu Chen, Peng Zhai
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Abstract
The present disclosure provides fusion polypeptides comprising serum albumin binding single domain antibody and GDF15, the polypeptide complexes thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
Claims23
A fusion polypeptide comprising, from N terminus to C terminus, a serum albumin binding single domain antibody, a polypeptide linker and a GDF15:
- wherein the single domain antibody comprises a VHH domain, wherein the VHH domain comprises a complementarity determining region 1 (CDR1) comprising the sequence of SEQ ID NO:
- 1, a CDR2 comprising the sequence of SEQ ID NO:
- 2, and a CDR3 comprising the sequence of SEQ ID NO:
- 3;
- and
- wherein the polypeptide linker has a length of 40-80 amino acid residues, wherein the polypeptide linker comprises an amino acid sequence selected from the group consisting of SEQ NOs:
- 48-49 and 61.
4 more elements
Dependencies are inferred from the claim text.